August 1, 2025Pharmacological ResearchOpen Access

Nuclear Receptors CAR and PXR as Cardiometabolic Regulators

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CAR and PXR are crucial nuclear receptors involved in regulating metabolism and cardiometabolic functions.
PXR activation negatively affects lipid metabolism, increasing cholesterol levels and promoting hyperlipidemia.
In contrast, CAR activation is beneficial, reducing triglycerides and cholesterol, improving overall lipid homeostasis.
Understanding CAR and PXR's roles could influence therapeutic strategies for cardiovascular diseases and metabolic disorders.

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Review shows CAR and PXR influence lipid and glucose metabolism in human health, highlighting their potential roles in atherosclerosis.

Hukkanen et al. (2025) studied this question.

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