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August 1, 2025Open Access

TRP Channels in Skin Cancer: Focus on Malignant Melanoma

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Authors

DTDamian TwardakVHVita HavryliukMGMaciej Gagat

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Overview

Review reveals trp channels influence melanoma progression in skin cancer, indicating their potential as therapeutic targets.

Key Points

  • Malignant melanoma is a highly aggressive skin cancer with significant metastatic potential and treatment resistance.
  • TRP channels play a crucial role in melanoma by affecting key processes like proliferation, apoptosis, and metastasis.
  • Key TRP subfamilies, such as TRPM1 and TRPM7, exhibit different functions in melanoma, acting as either tumor suppressors or drivers.
  • Exploring TRP channels as diagnostic biomarkers and therapeutic targets is essential for personalized treatment strategies.

Cite This Study

Twardak et al. (2025) studied this question.

synapsesocial.com/papers/689a0c65e6551bb0af8cfb8ehttps://doi.org/10.20944/preprints202507.2657.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TRP Channels in Skin Cancer: Focus on Malignant Melanoma2025
  2. 2TRP channels and cancer modulation: a voyage beyond metabolic reprogramming, oxidative stress and the advent of nanotechnologies in targeted therapy2025
  3. 3Rewiring melanoma cell fate: TRPM8 modulators trigger apoptosis and boost NK cell cytotoxicity2026
  4. 4Immunohistochemical Analysis of pH-Sensitive TRPV5 in Common Skin Tumors2026
  5. 5Exploring TRPM7 Channel-Kinase for Disease Modulation: A Translational Approach2026