Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 2025Open Access

Assessing cellular metabolic dynamics with NAD(P)H fluorescence polarization imaging

View Full Paper
Ask AI
Bookmark
Share

Authors

WZWarren R. ZipfelLLLing LuJCJack C. Crowley

Discussion

Loading...

Member takes

Overview

Two-photon microscopy tracks cellular metabolism in cancer cells, suggesting a new non-invasive monitoring approach.

Key Points

  • MAIN FINDING: FPRM effectively tracks cellular metabolism using NAD(P)H fluorescence for cancer research.
  • KEY EVIDENCE: The method shows substantial speed improvement over traditional FLIM, enabling real-time monitoring.
  • APPROACH: Two-photon steady-state fluorescence polarization microscopy offers high-resolution metabolic data on cells.
  • SIGNIFICANCE: This method enhances understanding of cancer metabolism, aiding in the development of new therapeutic strategies.

Cite This Study

Zipfel et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfc3chttps://doi.org/10.1101/2025.07.28.667273
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electromagnetic diffraction in optical systems, II. Structure of the image field in an aplanatic system1959 · 3,073 citations
  2. 2NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential2020 · 1,093 citations
  3. 3BRENDA, the ELIXIR core data resource in 2021: new developments and updates2020 · 845 citations
  4. 4<i>In vivo</i> multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia2007 · 1,029 citations
  5. 5Mapping metabolic changes by noninvasive, multiparametric, high-resolution imaging using endogenous contrast2018 · 184 citations