Supplementary Figure 4 from HER1 (EGFR) and/or HER2 Inclusion Potentiates the Antitumor Effect Elicited by a HER3-Specific Monovalent Vaccine

Ernesto Bermúdez-Abreut; Gretchen Bergado; Talia Fundora-Barrios; Jessica Arencibia-Perezleo; Armando López Medinilla; Lisset Chao; Belinda Sánchez-Ramírez

doi:10.1158/1535-7163.29761162

August 1, 2025

Supplementary Figure 4 from HER1 (EGFR) and/or HER2 Inclusion Potentiates the Antitumor Effect Elicited by a HER3-Specific Monovalent Vaccine

View at Publisher

Ask AI

Bookmark

Share

Key Points

MAIN FINDING: HER1 and HER2 inclusion significantly enhances the antitumor effect of a HER3-specific vaccine.
KEY EVIDENCE: Experimentation demonstrated stronger immune recognition by PAbs against HER1, HER2, and HER3 ECDs.
APPROACH: The study utilized rabbit immunization to generate PAbs for evaluating multiple HER3 vaccine candidates.
SIGNIFICANCE: Findings suggest that targeting multiple HER receptors could improve cancer vaccine strategies.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Preclinical data show increased antitumor effects with HER1 and HER2 in models using HER3-based vaccines, indicating potential for improved cancer therapies.

Abstract

Recognition of HER1-ECD, HER2-ECD and HER3-ECD by PAbs generated in rabbits by immunization with the three HER3-based vaccine candidates.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Bermúdez-Abreut et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfc93 https://doi.org/10.1158/1535-7163.29761162

View at Publisher

Ask AI

Bookmark

Share

Supplementary Figure 4 from HER1 (EGFR) and/or HER2 Inclusion Potentiates the Antitumor Effect Elicited by a HER3-Specific Monovalent Vaccine

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 4 from HER1 (EGFR) and/or HER2 Inclusion Potentiates the Antitumor Effect Elicited by a HER3-Specific Monovalent Vaccine

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading