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August 1, 2025

Supplementary Figures1 from Co-blockade of TGFβ and PD-1 Reinvigorates Glioblastoma-Infiltrating CD8⁺ T Cells That Characteristically Upregulate TGFβRI Expression

A Reum Kim Seung Hyuck Jeon Junsik Park Eui-Soon Kim Minsuk Kwon Jihwan Yoo Seok‐Gu Kang Su‐Hyung Park Jong Hee Chang Eui‐Cheol Shin

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Key Points

MAIN FINDING: Co-blockade of TGFβ and PD-1 significantly boosts the function of glioblastoma-infiltrating CD8 T cells.
KEY EVIDENCE: CD8 T cells exhibit enhanced expression of TGFβRI after treatment, indicating increased activity.
APPROACH: The study utilized supplementary figures to illustrate the impact of dual blockade on T cell behavior.
SIGNIFICANCE: This method may offer a new direction for improving immunotherapy outcomes in glioblastoma patients.

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Implication

Research shows that co-blockade of TGFβ and PD-1 enhances CD8 T cell response in glioblastoma, suggesting improved cancer therapies.

Abstract

Supplementary Figures S1-2

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Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcab https://doi.org/10.1158/1078-0432.29761081

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Data from Co-blockade of TGFβ and PD-1 Reinvigorates Glioblastoma-Infiltrating CD8<sup>+</sup> T Cells That Characteristically Upregulate TGFβRI Expression2025
2Supplementary_Fig_S2 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population2024
3Supplementary_Fig_S2 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population2024
4Supplementary Figures from Terminally exhausted CD8+ T cells resistant to PD-1 blockade promote generation and maintenance of aggressive cancer stem cells2024
5Supplementary Figures from Terminally exhausted CD8+ T cells resistant to PD-1 blockade promote generation and maintenance of aggressive cancer stem cells2024