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August 1, 2025

Efficacy of immunotherapy in older patients with triple-negative breast cancer: a systematic review

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Authors

CSCarrie ShaMLMarie LiuASAshley Schreier

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Overview

Systematic review finds limited efficacy of immune checkpoint inhibitors in patients aged 65 and older, highlighting research gaps.

Key Points

  • Limited data from RCTs show immune checkpoint inhibitors have unclear efficacy for older patients with triple-negative breast cancer.
  • Only four RCTs provided results for patients aged 65 and older, representing 18.7% of the total participants.
  • Key studies such as KEYNOTE 355 and IMPASSION 130 indicate varying outcomes but lack statistical significance for older patients.
  • The findings emphasize the urgent need for further research on immunotherapy efficacy in older triple-negative breast cancer patients.

Cite This Study

Sha et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfd60https://doi.org/10.21203/rs.3.rs-7024355/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effectiveness and Safety of Immune Checkpoint Inhibitors in Older Cancer Patients2024 · 1 citations
  2. 2Do age and performance status matter? A systematic review and network meta-analysis of immunotherapy studies in untreated advanced/metastatic non-oncogene addicted NSCLC2025 · 7 citations
  3. 3Immune checkpoint inhibitors combined with chemotherapy vs chemotherapy alone in advanced or metastatic triple-negative breast cancer: a systematic review and random-effects meta-analysis of randomized controlled trials2026
  4. 4Immunotherapy in older adults with gynecologic cancers: rethinking age as a limiting factor.2025
  5. 5Immunotherapy related patient-reported outcomes from five randomized controlled trials in patients with triple negative breast cancer: A systematic review.2024