August 2, 2025Open Access

Disrupting the Clock: Meta-Analysis of Irregular Night Shifts and Migraine, Proposing Shift Work Migraine Disorder with Chronobiology Strategies

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Meta-analysis shows irregular night shifts elevate migraine odds in workers, highlighting the role of circadian rhythms.

Irregular night shifts significantly increase migraine odds, with an odds ratio of 1.61 for affected workers.
A total of 13 high-quality cross-sectional studies were analyzed, with nearly 39 million participants reported.
Females showed higher odds for migraines, ranging between 2.02 to 4.21 in irregular night shifts.
Chronobiology strategies, including adjusted sleep schedules, may help mitigate migraine risk in shift workers.

Woldeamanuel et al. (2025) studied this question.

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