Ifosfamide-induced Catatonia – A Rare Presentation and Review of Ifosfamide-induced Central Nervous System Toxicity Along With Therapeutic Approaches

Ifosfamide is a well-known chemotherapeutic agent used to treat various cancer types but is associated with central nervous system toxicity, termed ifosfamide-induced encephalopathy (IIE). Rarely, this toxicity manifests as catatonia. We present the case of a 61-year-old woman with diffuse large B-cell lymphoma who developed profound catatonia after ifosfamide infusion. Her symptoms resolved completely following a single intravenous dose of lorazepam. This case underscores the importance of recognizing catatonia as a manifestation of IIE and supports the use of lorazepam as both a diagnostic and therapeutic intervention.