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August 2, 2025

High doses of ferric derisomaltose and ferric carboxymaltose both increase FGF-23 levels and lead to osteomalacia and bone loss in healthy male mice

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Authors

XLXuan-Thanh Le-PhuocVPVanessa PassinMLMaría G. Ledesma-Colunga

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Overview

Repeated high doses of FCM and FDI reduced bone volume and increased FGF-23 in healthy male mice, indicating potential risks for bone health.

Key Points

  • High doses of ferric carboxymaltose and ferric derisomaltose significantly reduced bone formation in healthy mice.
  • Ferric carboxymaltose resulted in a greater loss of bone volume compared to ferric derisomaltose (-36% vs -24%).
  • Mice treated with FCM and FDI showed marked increases in serum FGF-23 levels, indicating altered bone metabolism.
  • The study highlights potential risks of iron formulations, suggesting caution in their use for treating iron deficiency.

Cite This Study

Le-Phuoc et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0066https://doi.org/10.21203/rs.3.rs-7048209/v1
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