Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 2, 2025

Dissecting Non-Small Cell Lung Cancer (NSCLC) with Blood Proteomics - From Surgical to Immunotherapeutic Responses

View Full Paper
Ask AI
Bookmark
Share

Authors

VNVahid Yaghoubi NaeiAKA. KilgallonGMG. Q. Mendes

Discussion

Loading...

Member takes

Overview

Analysis reveals unique blood protein signatures linked to surgical resection and immunotherapy response in NSCLC patients, suggesting implications for biomarker discovery.

Key Points

  • Core contribution identifies distinct plasma protein signatures related to surgical and immunotherapy responses in NSCLC.
  • Evidence shows measurable plasma changes, including higher MUC16 and lower IL36G post-surgery for non-recurrent patients.
  • Methods include high-plex and high-sensitivity proteomics on blood samples from 56 NSCLC patients collected at various treatment stages.
  • Significance lies in advancing non-invasive blood tests for better biomarker identification and prognostic assessment in NSCLC.

Cite This Study

Naei et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0075https://doi.org/10.21203/rs.3.rs-7118825/v1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biological insights from plasma proteomics of non-small cell lung cancer patients treated with immunotherapy2024 · 13 citations
  2. 2Abstract 106: Integrated plasma multi-omics profiling identifies circulating predictive biomarkers and biological pathways associated with treatment response in NSCLC.2026
  3. 3Abstract 1186: Plasma proteomic profiling of lung cancer blood samples reveals immune-related inflammatory signatures as prognostic biomarkers.2026
  4. 4Abstract 1054: Plasma metabolomic profiling predicts response to neoadjuvant immunochemotherapy in locally advanced NSCLC2026
  5. 5Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic Non–Small Cell Lung Cancer2024 · 21 citations