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August 2, 2025Clinical and Applied Thrombosis/HemostasisOpen Access

Evaluating the Efficacy and Safety of Direct Oral Anticoagulants Compared to Vitamin K Antagonists in Patients with Antiphospholipid Syndrome: Updated Systematic Review and Meta-Analysis

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Authors

LALama AlfehaidNANada AlsuhebanyHAHussah N Albahlal

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Overview

Systematic review finds DOACs increase arterial thrombosis risk in antiphospholipid syndrome patients, suggesting caution.

Key Points

  • Core analysis shows no significant difference in venous thromboembolism rates between DOAC and VKA.
  • Triple-positive APS patients have a threefold higher risk of thromboembolism recurrence with DOAC.
  • Meta-analysis involved 11 studies with 1813 participants, ensuring robust data evaluation.
  • Findings indicate that while DOACs are comparably safe, they raise arterial thrombosis risk, favoring warfarin.

Cite This Study

Alfehaid et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d00cchttps://doi.org/10.1177/10760296251364269
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