Supplementary Figure S1 from Repurposing the DNA Labeling Agent EdU for Therapy against Heterogeneous Patient Glioblastoma

Figure S1: Illustration of the proposed futile cycle induced by the incorporation of EdU by DNA polymerases and removal of it by excision repair. EdU gets incorporated into the genome of highly proliferative GBM cells in the brain. Then, EdU-containing DNA is recognized and removed by nucleotide excision repair, leaving the DNA gap to be filled in. During the resynthesis, EdU reincorporates into this repair patch and the futile cycle repeats, leading to apoptosis and thus, suppression of the growth of GBM tumor.