Supplementary Figure S2 from Detection of Early-Stage Colorectal Cancer Using Cell-Free oncRNA Biomarkers and Artificial Intelligence

Supplementary Figure S2. a) Model scores increase with overall stage (left panel), T stage (middle panel) and N stage (right panel). Statistical significance is determined using a one-sided Mann-Whitney U-test. b) Overall sensitivity and specificity across different subgroups at 90% specificity in the training set. Dashed lines indicate the overall sensitivity and specificity. Confidence intervals are derived using the Pearson-Clopper method. c) The model’s sensitivity remains robust across tumor locations within the colon and rectum in the training set. Confidence intervals are calculated using the Pearson-Clopper method d) The model’s sensitivity remains robust across tumor types. Confidence intervals are calculated using the Pearson-Clopper method