August 2, 2025Frontiers in PediatricsOpen Access

The Ex-utero intrapartum treatment procedure: a narrative review

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Narrative review discusses cesarean delivery techniques for fetal interventions, indicating benefits and risks for mothers and newborns.

The EXIT procedure allows life-saving fetal interventions while maintaining placental circulation during cesarean delivery.
It has been successfully used for conditions like congenital diaphragmatic hernias and airway compression, showing high perinatal survival rates.
Accurate prenatal diagnosis through fetal ultrasound and imaging is crucial for the EXIT procedure's success and safety.
While it can be performed safely in specialized centers, maternal and fetal risks should be carefully considered during the procedure.

Gaffuri et al. (2025) studied this question.

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