August 2, 2025Frontiers in ImmunologyOpen Access

TOX, through a glass, darkly

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Authors

PHPatrick G. HoganLa Jolla Institute for Immunology BRBruno Villalobos RevelesLa Jolla Institute for Immunology LVLeo Josue Arteaga Vazquez

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Implication

Inquiry reveals how TOX, an HMG-box transcription factor, influences CD8+ T cell exhaustion and immune cell processes, suggesting new research directions.

Key Points

TOX is highlighted as a key transcription factor involved in CD8+ T cell exhaustion.
The role of TOX as an HMG-box protein is linked to its DNA binding characteristics.
Mechanisms employed by other HMG-box proteins provide insight into TOX's functions.
Understanding TOX may help advance research on T cell exhaustion and immune responses.

Cite This Study

Hogan et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d048d https://doi.org/10.3389/fimmu.2025.1576468

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Implication

Inquiry reveals how TOX, an HMG-box transcription factor, influences CD8+ T cell exhaustion and immune cell processes, suggesting new research directions.

TOX, through a glass, darkly

Discussion

Member takes

Implication

Key Points

Cite This Study

TOX, through a glass, darkly

Discussion

Member takes

Implication

Key Points

Cite This Study

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