Potential role of AhR in ischemia‑reperfusion injury and cancers: Focus on ferroptosis and lipid peroxidation signaling pathways (Review)

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Review highlights how AhR regulates lipid peroxidation and ferroptosis in ischemia-reperfusion injury and cancer, suggesting therapeutic targets.

AhR is a key factor in maintaining redox homeostasis, impacting disease processes like cancer and ischemia-reperfusion injury.
Disruption of redox balance leads to lipid peroxidation, which is associated with ferroptosis and various diseases.
Targeting AhR can potentially improve therapeutic strategies for both cancer treatment and neurodegenerative disease prevention.
Understanding AhR's role in lipid peroxidation could lead to novel therapies for ischemia-reperfusion injury and cancer management.

Liao et al. (2025) studied this question.

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Review highlights how AhR regulates lipid peroxidation and ferroptosis in ischemia-reperfusion injury and cancer, suggesting therapeutic targets.