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August 2, 2025Frontiers in ImmunologyOpen Access

From laboratory to clinic: a precise treatment strategy of mesenchymal stem cells-derived exosomes pretreated by simulating disease microenvironment

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Authors

HYHailian YeZunyi Medical UniversityQHQi HeNortheast Agricultural UniversityFQFang QiFujian Medical University

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Implication

This review examines preconditioning effects on MSC-derived exosomes in various diseases, suggesting precision medicine approaches for better outcomes.

Key Points

  • Mesenchymal stem cells and their exosomes show promise for tissue repair in various diseases.
  • The efficacy of MSC-derived exosomes is influenced by the disease microenvironment, necessitating tailored strategies.
  • Novel preconditioning methods using diseased tissue characteristics enhance exosome therapy effectiveness.
  • Engineering exosomes with specific miRNAs offers new avenues for improving disease treatment in precision medicine.

Cite This Study

Ye et al. (2025) studied this question.

synapsesocial.com/papers/689a0c7be6551bb0af8d04a8https://doi.org/10.3389/fimmu.2025.1609288
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  4. 4Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment2018 · 450 citations
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