August 3, 2025Open Access
Metabolic profiling and longitudinal changes in patients with severe aortic stenosis undergoing valve replacement
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Implication
Longitudinal analysis reveals changes in metabolic profiling and cardiac function in aortic stenosis patients post-valve replacement, suggesting implications for mortality risk.
Key Points
- Reduced free fatty acids and branched chain amino acids are associated with greater myocardial mass in patients with aortic stenosis.
- Lower concentrations of free fatty acids and branched chain amino acids correlate with a higher mortality risk over 10.5 years post-valve replacement.
- Patients underwent cardiac magnetic resonance and serum biomarker analysis before and after aortic valve replacement.
- Understanding metabolic changes in aortic stenosis may inform future guidelines for valve replacement timing and metabolic interventions.
Cite This Study
Nitsche et al. (2025) studied this question.