August 3, 2025Biomolecules and BiomedicineOpen Access

Influence of intravenous iron therapy on mortality and cardiovascular events of patients on hemodialysis: A meta-analysis

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Intravenous iron therapy shows no significant effect on all-cause mortality in hemodialysis patients (OR: 1.36; 95% CI: 0.60–3.09).
Major adverse cardiovascular events remain unaffected by IV iron compared to placebo or oral iron (OR: 0.81; 95% CI: 0.43–1.55).
High-dose IV iron may lower mortality rates compared to low doses (OR: 0.81; 95% CI: 0.67–0.97), yet only a single study strongly influences this finding.
The overall quality of evidence regarding IV iron impacts calls for further studies to clarify its safety profile in this population.

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Implication

Meta-analysis reveals no significant impact of IV iron on mortality or cardiovascular events in hemodialysis patients, indicating further research is needed.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/689a0c7be6551bb0af8d0821 https://doi.org/10.17305/bb.2025.12652

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Implication

Meta-analysis reveals no significant impact of IV iron on mortality or cardiovascular events in hemodialysis patients, indicating further research is needed.

Influence of intravenous iron therapy on mortality and cardiovascular events of patients on hemodialysis: A meta-analysis

Key Points

Discussion

Implication

Cite This Study

Influence of intravenous iron therapy on mortality and cardiovascular events of patients on hemodialysis: A meta-analysis

Key Points

Discussion

Implication

Cite This Study

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