Unraveling Liver Cirrhosis: Bridging Pathophysiology to Innovative Therapeutics

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This review uncovers the role of hepatic stellate cells and the gut microbiome in liver cirrhosis, indicating potential therapeutic avenues.

Liver cirrhosis is a progressive condition resulting from chronic inflammation and sustained liver injury.
Emerging interventions aim to modify disease progression and may offer new hope for patients with cirrhosis.
The gut microbiome plays a critical role in disease dynamics, influencing inflammation and progression.
Recent advancements in diagnostics, including noninvasive tools, are paving the way for better management of liver cirrhosis.

Rabab A. Hegazy (2025) studied this question.

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This review uncovers the role of hepatic stellate cells and the gut microbiome in liver cirrhosis, indicating potential therapeutic avenues.