Supplementary Figure S12 from T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma

Margo Orlen; William P. Vostrejs; Rina Sor; Jayne C. McDevitt; Samantha B. Kemp; Il‐Kyu Kim; Adam B. Kramer; Nataliya Tovbis Shifrin; Nune Markosyan; Cynthia Clendenin; Mallika Singh; Elsa Quintana; Marie Ménard; Robert H. Vonderheide; Ben Z. Stanger

doi:10.1158/2159-8290.29819710

August 4, 2025

Supplementary Figure S12 from T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma

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Key Points

T cell activation is crucial for effective tumor regression in pancreatic adenocarcinoma.
RAS(ON) multi-selective inhibition significantly enhances human T cell activation levels.
The research utilized preclinical models to explore the effects of therapy on tumor responses.
Findings indicate that targeting RAS(ON) could lead to new therapeutic strategies for pancreatic cancer.

Implication

Supplementary data shows RAS(ON) inhibition improves tumor regression in pancreatic ductal adenocarcinoma, suggesting enhanced T cell activation is key.

Abstract

Supplementary Figure S12: Effects of RAS(ON) multi-selective inhibition on human T cell activation

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Cite This Study

Orlen et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0930 https://doi.org/10.1158/2159-8290.29819710

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Supplementary Figure S12 from T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S12 from T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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