Supplementary Figure S3 from T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma

Margo Orlen; William P. Vostrejs; Rina Sor; Jayne C. McDevitt; Samantha B. Kemp; Il‐Kyu Kim; Adam B. Kramer; Nataliya Tovbis Shifrin; Nune Markosyan; Cynthia Clendenin; Mallika Singh; Elsa Quintana; Marie Ménard; Robert H. Vonderheide; Ben Z. Stanger

doi:10.1158/2159-8290.29819704

August 4, 2025

Supplementary Figure S3 from T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma

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Key Points

T-cell dependency plays a crucial role in tumor regressions and complete responses in pancreatic ductal adenocarcinoma.
The study highlights significant effects of ras(on) multi-selective inhibition on stroma and vasculature in PDAC tumors.
Preclinical models were utilized to assess how ras(on) influences tumor dynamics and immune interactions.
Understanding these mechanisms may advance therapeutic strategies for pancreatic ductal adenocarcinoma treatment.

Implication

Supplementary figure demonstrates ras(on) multi-selective inhibition influences tumor vasculature in pancreatic ductal adenocarcinoma, suggesting a role for T-cell activation.

Abstract

Supplementary Figure S3: Effects of RAS(ON) multi-selective inhibition on stroma and vasculature in implanted PDAC tumors

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Cite This Study

Orlen et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d095a https://doi.org/10.1158/2159-8290.29819704

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Supplementary Figure S3 from T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S3 from T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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