⌘+K

Pulse Explore Communities Researchers Journals

Browser extensionInstagram

Home Communities Explore

August 4, 2025

Supplementary Figure S1 from METTL3 Promotes Gastric Cancer Progression via Modulation of FNTA-Mediated KRAS/ERK Signaling Activation

Fangqi Hu Song Zhang Jie Chai

View at Publisher

Ask AI

Bookmark

Share

Key Points

MAIN FINDING: METTL3 promotes gastric cancer progression, indicating its potential as a therapeutic target.
KEY EVIDENCE: METTL3 deficiency alters FNTA signaling, which affects KRAS/ERK pathways in gastric cells.
APPROACH: Analysis was conducted on human normal gastric mucosal epithelial cells to assess METTL3's role.
SIGNIFICANCE: Understanding METTL3's impact could lead to new strategies for treating gastric cancer effectively.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Ask your own question…

Implication

Experimental findings demonstrate METTL3's role in gastric cancer signaling, implicating FNTA and ERK activation in epithelial cells.

Abstract

The influence of METTL3 deficiency in human normal gastric mucosal epithelial cells

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0980 https://doi.org/10.1158/1541-7786.29819563

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S3 from METTL3 Promotes Gastric Cancer Progression via Modulation of FNTA-Mediated KRAS/ERK Signaling Activation2025
2Supplementary Figure S2 from METTL3 Promotes Gastric Cancer Progression via Modulation of FNTA-Mediated KRAS/ERK Signaling Activation2025
3Data from METTL3 Promotes Gastric Cancer Progression via Modulation of FNTA-Mediated KRAS/ERK Signaling Activation2025
4Supplementary Figure S9 from TERC Stimulates Fatty Acid Metabolism to Promote Bladder Cancer Progression2025
5METTL3-Regulated lncRNA SNHG7 Drives MNNG-Induced Epithelial–Mesenchymal Transition in Gastric Precancerous Lesions2024 · 12 citations
6Methyltransferase‐Like 3 in Gastric Cancer: Advances in Understanding Its Intricate Roles and Therapeutic ImplicationsReview · 2025
7Figure S3 from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells2024
8DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 DecayOriginal Research · 2026