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August 4, 2025

Progression of Peripheral Blood Mononuclear Cell Mitochondrial Function during the Early Phase of Sepsis in Intensive Care Unit Patients

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Authors

AZArthur R. H. van ZantenHMHanneke Pierre Franciscus Xaverius MoonenRSRianne Slingerland

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Overview

Prospective cohort study reveals increased mitochondrial respiration in sepsis patients, suggesting links to mortality and clinical outcomes.

Key Points

  • Increased mitochondrial respiration was observed in peripheral blood mononuclear cells during early sepsis.
  • Respiration measures included basal, ATP-linked, and maximal rates in 25 sepsis patients compared to 24 controls.
  • Higher basal respiration rates correlated with a 3-month mortality hazard ratio of 3.794, indicating potential severity indicators.
  • Study findings imply mitochondrial function could serve as a useful marker for predicting clinical outcomes in sepsis.

Cite This Study

Zanten et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0b48https://doi.org/10.21203/rs.3.rs-7137135/v1
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