August 4, 2025

Reduction in Onchocerca volvulus infection prevalence and intensity in Logo Health Zone in Ituri, Democratic Republic of the Congo, in the absence of interventions: Results of screening for clinical trials of moxidectin vs. ivermectin in 2010 and 2021-2023

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Screening reveals significant drop in infection prevalence among volunteers in Ituri, suggesting shifting transmission dynamics.

Infection prevalence of onchocerca volvulus dropped significantly from 23.3% in 2010 to 89.8% in 2021-2023.
The mean microfilariae density fell from 24.30 in 2010 to only 1.1 in 2021-2023, indicating reduced infection intensity.
No ivermectin was used during the study, suggesting changes in vector biting rates may be responsible for infection reduction.
Changes in land-use appear linked to the emergence of different vector species that may have impacted transmission rates.

Ngave et al. (2025) studied this question.

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