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August 4, 2025Clinical Transplantation

Emerging Therapeutic Strategies for Renal Ischemia‐Reperfusion Injury in Kidney Transplantation: Progress and Challenges—A Systematic Review

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Authors

SKSohail KhanDZDayanna ZuluagaLRLloyd E. Ratner

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Overview

Systematic review evaluates investigational therapies for renal ischemia-reperfusion injury in kidney transplantation, indicating challenges in clinical translation.

Key Points

  • Ischemia-reperfusion injury contributes significantly to delayed graft function and allograft loss during transplantation.
  • A systematic search identified 43 eligible reports on pharmacologic interventions for renal ischemia-reperfusion injury.
  • Recent therapeutic strategies include alkaline phosphatase and MSC-derived exosomes, which are in early development stages.
  • Future research should focus on harmonized models and biomarkers for effective integration of therapies into kidney transplant care.

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/689a0f8de6551bb0af8d0ee6https://doi.org/10.1111/ctr.70263
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