This review examines gene expression and protein modifications in the brain, highlighting the complex dynamics of sleep homeostasis across different ages and cell types.
This review describes how transcriptomic/proteomic studies have contributed identifying molecular markers of sleep homeostasis and offers a perspective on the need to interrogate more comprehensively different dynamics, brain regions, and cell types. Modifications in molecular dynamics with development/aging are also emphasized. We suggest the concept of sleep homeostasis to be regarded as a variety of homeostats (not a single one) serving different functions for the brain across the lifespan.
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Mongrain et al. (2025) studied this question.
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