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August 4, 2025Experimental & Molecular MedicineOpen Access

Guardians of silence: transcriptional networks in T cell quiescence

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Authors

JCJin Ouk ChoiYSY.G. SeoSeoul National UniversitySHSoo Seok HwangGyeongsang National University

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Implication

The review highlights transcriptional regulation of T cell quiescence, suggesting implications for autoimmunity and tumor control.

Key Points

  • T cells remain inactive during quiescence to avoid unwanted immune responses while being ready for activation.
  • Extrinsic signals trigger T cells to leave their quiescent state and rapidly proliferate.
  • The regulation of T cell quiescence involves complex transcriptional and post-transcriptional mechanisms.
  • Understanding T cell quiescence aids in addressing diseases like autoimmunity and improving tumor control strategies.

Cite This Study

Choi et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d1011https://doi.org/10.1038/s12276-025-01516-y
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