Revolutionizing Caffeic Acid Production: Advanced Microbial Metabolic Engineering and Synthetic Biology Approaches

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This review highlights strategies to optimize caffeic acid production in microbial systems, suggesting integration could boost yields.

Caffeic acid is a valuable phenolic compound important for various applications in food and medicine.
Five strategies enhance caffeic acid production: biosynthetic pathway modification, cofactor engineering, and more.
Microbial chassis used for production face challenges like precursor availability and toxicity from intermediates.
Integrating these strategies aims to overcome production bottlenecks and improve caffeic acid yields.

Lu et al. (2025) studied this question.

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