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August 5, 2025Journal of Clinical MedicineOpen Access

Novel Biomarkers for Rejection in Kidney Transplantation: A Comprehensive Review

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Authors

MSMichael Brad StraderUniversity College DublinSKSam KantUniversity College Dublin

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Implication

Comprehensive review highlights novel biomarkers that improve diagnostic performance in kidney transplantation, suggesting better immunosuppression management.

Key Points

  • Novel biomarkers offer improved sensitivity for early detection of rejection in kidney transplantation.
  • Conventional monitoring tools like serum creatinine have limitations in identifying graft injury.
  • Biopsies remain the gold standard but are invasive and carry procedural risks.
  • Personalized immunosuppressive strategies can benefit from the use of emerging biomarkers in clinical practice.

Cite This Study

Strader et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d11f7https://doi.org/10.3390/jcm14155489
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevation of Donor-derived Cell-free DNA Before Biopsy-proven Rejection in Kidney Transplant2024 · 52 citations
  2. 2Antigenic diversity and seroprevalences of Torque teno viruses in children and adults by ORF2-based immunoassays2012 · 33 citations
  3. 3Digital Droplet PCR for Rapid Quantification of Donor DNA in the Circulation of Transplant Recipients as a Potential Universal Biomarker of Graft Injury2013 · 274 citations
  4. 4Impact of induction agents and maintenance immunosuppression on torque teno virus loads and year-one complications after kidney transplantation2024 · 13 citations
  5. 5Biomarkers in acute kidney injury: On the cusp of a new era?2023 · 18 citations