The study reveals a novel RNAylation method for creating nucleic acid-protein conjugates, highlighting its potential in synthetic biology and therapeutics.
Key Points
RNAylation provides a robust method for generating nucleic acid-protein conjugates with site specificity.
The approach utilizes a natural enzymatic reaction that enhances nucleic acid stability in human cell lysates.
An effective purification workflow was developed for the generated conjugates, facilitating further applications.
Successful delivery of conjugates into human cells demonstrates the method's potential for functional in vivo applications.