August 6, 2025

A critical role for VE-cadherin in regulating actin dynamics during endothelial maturation and non-inflammatory activation via a tension-sensitive intermediate state

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Authors

JFJ. FränzUniversity of Münster MOMaria Odenthal-SchnittlerUniversity of Münster JKJan Philip KipckeUniversity of Münster

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Implication

Research reveals that VE-cadherin regulates actin dynamics during endothelial maturation and shear stress response, indicating its role in maintaining barrier function.

Key Points

VE-cadherin plays a critical role in endothelial maturation by strengthening junctional actin recruitment for a stable monolayer.
A novel intermediate state is identified that enhances actin and integrin recruitment during non-inflammatory activation.
The study uses human umbilical vein endothelial cells (HUVEC) to investigate mechanisms of monolayer maturation and remodeling.
Findings offer insight into mechanotransduction, showing how endothelial cells adapt to shear stress for cell protection.

Cite This Study

Fränz et al. (2025) studied this question.

synapsesocial.com/papers/689a0f99e6551bb0af8d1681 https://doi.org/10.1101/2025.08.05.668624

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Implication

Research reveals that VE-cadherin regulates actin dynamics during endothelial maturation and shear stress response, indicating its role in maintaining barrier function.

A critical role for VE-cadherin in regulating actin dynamics during endothelial maturation and non-inflammatory activation via a tension-sensitive intermediate state

Discussion

Member takes

Implication

Key Points

Cite This Study

A critical role for VE-cadherin in regulating actin dynamics during endothelial maturation and non-inflammatory activation via a tension-sensitive intermediate state

Discussion

Member takes

Implication

Key Points

Cite This Study

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