Effect of uric acid on the progression of Parkinson’s disease: Myth or reality?

Numerous studies showed an association between Parkinson’s disease and low uric acid levels. Low uric acid levels are associated with an increased risk of Parkinson’s disease, its progression, and the severity of symptoms. Although the biological mechanisms for this association have not yet been established, it is suggested that uric acid acts as an antioxidant, reducing oxidative stress and protecting dopaminergic neurons. However, some recent studies question this hypothesis. The article discusses the biological properties of uric acid, its relationship to Parkinson’s disease, and the possibility of reverse causation, where the disease causes a decrease in uric acid levels. The presented data support further research to understand these relationships more deeply, possibly leading to new disease treatment approaches.