August 6, 2025Open Access

Cell competition overcomes host tissue resistance to unleash tumour growth in a Drosophila brain cancer model

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Tumour growth in Drosophila demonstrates how competition alters host tissue dynamics.
Blocking cortex glia cell death leads to reduced tumour expansion, highlighting resistance mechanisms.
Transcriptional profiling shows a biphasic reaction of cortex glia to tumour growth stages.
JNK signalling initially protects against tumour progression but later fails, facilitating tumour development.

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Experimental model reveals host tissue resistance influences tumour progression, suggesting strategies for treatment.

Gualtieri et al. (2025) studied this question.

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