Resistance of Gram-Negative Bacteria to Cefepime-Enmetazobactam: A Systematic Review
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Implication
Systematic review evaluates resistance to cefepime-enmetazobactam in multidrug-resistant Gram-negative bacteria, indicating varying efficacy against different β-lactamases.
Key Points
- The study assesses the resistance of Gram-negative bacteria to cefepime-enmetazobactam.
- Resistance was low for ESBL and AmpC producers, but significantly higher for OXA-48 and KPC producers.
- Analysis included data from 15,408 isolates across ten studies on antimicrobial resistance mechanisms.
- Findings suggest cefepime-enmetazobactam could be a carbapenem-sparing option for treating certain infections.
Cite This Study
Falagas et al. (2025) studied this question.