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August 6, 2025

Supplementary Fig. S5 from Evaluation of Ferroptosis as a Biomarker to Predict Treatment Outcomes of Cancer Immunotherapy

Zhijun Zhou Yang Cai Hao Yuan Qun Chen Sophia W. Zhao Jingxuan Yang Mingyang Liu Alex X. Arreola Yu Ren Chao Xu Lacey R. McNally Michael S. Bronze Courtney W. Houchen Kuirong Jiang Wei R. Chen Yuqing Zhang Min Li

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Key Points

Main finding indicates a strong association between ferroptosis levels and treatment outcomes in non-small cell lung cancer.
Key evidence shows that higher tumor mutational burden (TMB) correlates with increased ferroptosis activity.
Approach involved analyzing ferroptosis and TMB data from patients with non-small cell lung cancer.
Significance lies in identifying ferroptosis as a potential biomarker for predicting responses to cancer immunotherapy.

Implication

Evaluation of ferroptosis levels and TMB predicts treatment outcomes in NSCLC, highlighting their potential as biomarkers.

Abstract

Supplementary Fig. S5. Prognosis and TMB of non-small cell lung cancer (NSCLC) are associated with ferroptosis level.

Discussion

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Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/689a0fa0e6551bb0af8d17ed https://doi.org/10.1158/2767-9764.29836654

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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5Supplementary Figure S12 from Integrated Omics and Multicohort Analyses Identify an Enhancer Variant Linking Ferroptosis to Precision Therapy in Prostate Cancer2025

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