Comparative Efficacy and Recurrence of Combination Therapies in Keloid Management: A Systematic Review and Network Meta-analysis

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Discussion

Network meta-analysis shows combination therapies reduce recurrence in keloid patients, suggesting tailored treatment is crucial.

Combination therapies for keloid management have shown enhanced efficacy compared to TAC alone.
The NMA included data from 1398 cases across 22 RCTs evaluating various treatment combinations.
TAC combined with bleomycin or 5-FU and PDL exhibited significant improvements in recurrence rates.
Findings indicate the necessity for personalized, multimodal keloid treatment for better patient outcomes.

Chandra et al. (2025) studied this question.

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