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August 6, 2025Expert Review of Hematology

Reduced-intensity conditioning for allogeneic transplantation in classical Hodgkin lymphoma

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Authors

HNHiba NarvelGAGulrayz AhmedMHMehdi Hamadani

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Overview

Review compares reduced-intensity conditioning and myeloablative conditioning in allo-HCT for Hodgkin lymphoma, suggesting RIC improves outcomes.

Key Points

  • Reduced-intensity conditioning offers a favorable balance between efficacy and tolerability in allogeneic HCT.
  • Allogeneic HCT remains a potentially curative option for relapsed/refractory Hodgkin lymphoma patients.
  • Immune checkpoint inhibitors can enhance graft-versus-malignancy effects but may increase graft-versus-host disease risks.
  • Post-transplant cyclophosphamide allows safer use of alternative donors in transplantation without compromising outcomes.

Cite This Study

Narvel et al. (2025) studied this question.

synapsesocial.com/papers/689a0fa0e6551bb0af8d182dhttps://doi.org/10.1080/17474086.2025.2545336
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