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August 7, 2025Reviews in Cardiovascular MedicineOpen Access

Efficacy of Dual Glucagon and Glucagon-like Peptide-1 Receptor Agonists Across the Cardiometabolic Continuum: A Review of Current Clinical Evidence

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Authors

PSPanagiotis StachteasANAthina NasoufidouPKPaschalis Karakasis

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Overview

This review demonstrates improvements in glycated hemoglobin and body weight in patients, suggesting dual receptor agonists could transform cardiometabolic disease management.

Key Points

  • Dual glucagon and GLP-1 receptor agonists showed significant improvements in glycated hemoglobin levels and body weight.
  • Emerging evidence indicates these agents may enhance cardiovascular and renal outcomes in high-risk patients.
  • Clinical trials with survodutide and cotadutide outperform traditional therapies in efficacy metrics.
  • These next-generation treatments could redefine standards in precision medicine for metabolic diseases.

Cite This Study

Stachteas et al. (2025) studied this question.

synapsesocial.com/papers/689a0fa0e6551bb0af8d1a41https://doi.org/10.31083/rcm39691
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