Low-Dose Computed Tomography Lung Cancer Screening for Individuals Who Have Never Smoked: A Review of Recent Updates in Taiwan and the United States

Low-dose computed tomography (LDCT) screening is widely recognized as an effective tool for the early detection of lung cancer. However, its efficacy among individuals without a history of smoking continues to attract interest. Currently, nearly all lung cancer screening guidelines provide recommendations exclusively for individuals who currently smoke or have a history of smoking. Emerging research indicates that LDCT screening may also benefit individuals who have never smoked but are genetically predisposed to lung cancer or have been exposed to certain environmental risk factors. This underscores the need to consider expanding LDCT screening eligibility criteria to include carefully selected never-smokers at high risk, potentially preventing lung cancer-related deaths.