A mechanochemical method achieves high yields of quinoline derivatives in 30 min, highlighting eco-friendly synthesis.
A solvent‐free, mechanochemical synthesis of benzyl‐quinoline analogues is reported via a one‐pot multicomponent reaction of substituted aldehydes, benzyl‐3‐oxobutanoate, 5‐methylcyclohexane‐1,3‐dione, and ammonium acetate. Urea serves as an eco‐friendly catalyst, enabling high yields (93%–97%) within 30 min under grinding conditions. This method eliminates column chromatography, reduces waste, and avoids toxic solvents or harsh conditions, offering a cost‐effective and sustainable approach to quinoline derivatives.
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Balaramudu et al. (2025) studied this question.
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