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September 19, 2025Journal of Heterocyclic Chemistry

A Solvent‐Free One‐Pot Synthesis of Ethyl 4‐Oxo‐3,4‐Dihydro Quinazoline‐2‐Carboxylates Utilizing N‐(2‐Aminobenzoyl) Benzotriazoles

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Authors

NHNasir Ahmad HeraviSESultan Funda EktiİÇİlhami Çelik

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Overview

New solvent-free synthesis generates ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylates, highlighting efficiency and environmental benefits.

Key Points

  • Good yields of ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylates were obtained, reaching up to 85%.
  • The synthesis method utilizes diethyl oxalate and ammonium acetate without any solvent, enhancing efficiency and sustainability.
  • N-(2-aminobenzoyl) benzotriazoles play a crucial role in achieving the required chemical reactions in this new one-pot approach.
  • This method demonstrates a significant advance in organic synthesis, offering an eco-friendly alternative to traditional techniques.

Cite This Study

Heravi et al. (2025) studied this question.

synapsesocial.com/papers/68d466b531b076d99fa65715https://doi.org/10.1002/jhet.70088
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