Immunohistochemical analysis reveals altered Nf-kB expression in brain regions of type 1 diabetes models, suggesting potential therapeutic targets.
Objective. The aim of our study is to characterize the features of Nf-kВ expression in the primary somatosensory cortex (PSC) of the brain and the hippocampus in diabetic encephalopathy (DE). Based on the results of an immunohistochemical study of the PSC cortex, the following differences were found between intact animals and the group of type 1 diabetes mellitus (DM1) without treatment: in the group of type I diabetes without treatment, the expression of the immunoreactive material (IRM) Nf-kВ in the PSC was found mainly in the nuclei of damaged neurons, weakly expressed in the hippocampus expression in the cytoplasm of pericaryons of neurons. The expression of IRM Nf-kВ in the axons of neurons located vertically was found in intact animals in the PSC. In the group of DM1 without treatment, no expression of Nf-kВ was found in the vertical processes of PSC neurons.
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Tyurenkov et al. (2025) studied this question.
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