Features of intersystem integration in the body of women planning pregnancy, depending on the nature of morphofunctional asymmetries

The anabolic orientation of the metabolic restructuring vector during pregnancy is usually characterized as a «physiological metabolic syndrome». In some women, these changes lead to gestational diabetes mellitus (GDM), which causes obstetric complications and increases the risk of type 2 diabetes. It is of considerable interest to study the processes of intersystem integration in women at the pre-gestation stage, taking into account the lateral constitution that determines the nature of regulatory processes. Aim: Identification of the features of intersystem integration between various parts of the hormonal system, psycho-emotional status and blood system in women planning pregnancy, depending on the nature of the lateral behavioral profile of asymmetries. Materials and methods: Design is an observational, multicenter, prospective-retrospective, uncontrolled, non-blinded study. The lateral behavioral profile of asymmetries was determined using the Annette test, situational and personal anxiety using the Spielberger-Khanin test, hormone levels in the blood using enzyme immunoassay, hemogram and coagulogram parameters. Results: The highest incidence of GDM was recorded with an ambilateral behavioral profile of asymmetries. The prerequisites for the «disruption» of carbohydrate metabolism during pregnancy are a weakening of intersystemic integration (a decrease in correlations between indicators of hormonal and psychoemotional status, as well as the blood system) at the pregravidar stage. These disorders develop against the background of a decrease in the coefficient of interhemispheric asymmetry in women with ALP and with greater activity of the right hemispheric exchange-associated brain structures in this lateral subgroup. Conclusion: The results of the study expand the understanding of the mechanisms of intersystem integration in women at the pregravidar stage, depending on the lateral phenotype, and allow us to consider the ambidextral lateral phenotype as a risk factor for developing gestational diabetes mellitus.