The effect of the neuropeptide oxytocin on stress-related organs in rats subjected to prolonged stress

The classic vegetative manifestations of stress are involutional changes in the thymus, the appearance of ulcerative formations in the mucous membrane of the gastrointestinal tract, hypertrophy of the adrenal cortex. Active research is underway to find stress-protective substances among neuropeptides. Our focus is on the peptide neurotransmitter oxytocin. The study was conducted on 70 male Wistar rats. The stress load was simulated for 24 hours and 15 minutes before the stress exposure, the animals received substances: group B – saline solution; group C – oxytocin. Laparotomy was performed to extract the thymus, adrenal glands, spleen, and stomach to determine the severity of classical stress symptoms. The study demonstrated that intranasal administration of oxytocin has a positive effect on all stress marker organs during various observed periods. It has been established that after prolonged immobilization stress.