Chiral P,N,N-Ligands for the Manganese-Catalyzed Asymmetric Formal Hydroamination of Allylic Alcohols.

Qi Li; Xinyu Song; Zixin Wu; Ling Li; Tingting Zhu; Xinwei He; Chuan‐Jin Hou

doi:10.1021/acs.joc.5c01353

August 7, 2025

Chiral P,N,N-Ligands for the Manganese-Catalyzed Asymmetric Formal Hydroamination of Allylic Alcohols.

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Key Points

Chiral P,N,N-ligands enhance the manganese-catalyzed hydroamination of allylic alcohols.
The method achieves up to 93% yield and 96% enantiomeric excess of chiral γ-amino alcohols.
Various secondary amines successfully react with racemic allylic alcohols using this approach.
This work advances synthetic strategies in asymmetric chemistry, showing effective ligand design for catalysis.

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Implication

Application of chiral P,N,N-ligands improves yield of γ-amino alcohols in allylic alcohols, indicating effectiveness of manganese catalysts.

Abstract

Application of chiral P,N,N-ligands in the manganese-catalyzed formal asymmetric hydroamination of allylic alcohols through a borrowing-hydrogen strategy was demonstrated. A series of racemic allylic alcohols could react with various secondary amines, affording chiral γ-amino alcohols in up to 93% yield with 96% ee.

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Li et al. (2025) studied this question.

synapsesocial.com/papers/689dfe97d61984b91e13c107 https://doi.org/10.1021/acs.joc.5c01353

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Chiral P,N,N-Ligands for the Manganese-Catalyzed Asymmetric Formal Hydroamination of Allylic Alcohols.

Key Points

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Abstract

Discussion

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Chiral P,N,N-Ligands for the Manganese-Catalyzed Asymmetric Formal Hydroamination of Allylic Alcohols.

Key Points

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Implication

Abstract

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