August 7, 2025Frontiers in ImmunologyOpen Access

Single cell autofluorescence imaging reveals immediate metabolic shifts of neutrophils with activation across biological systems

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Discussion

Optical metabolic imaging shows rapid metabolic changes in neutrophils with activation, highlighting their role in immune responses.

Neutrophils shift to a reduced redox state upon activation, indicating rapid metabolic changes.
Heterogeneous metabolic responses to pathogens Pseudomonas aeruginosa and Toxoplasma gondii were observed in neutrophils.
Optical metabolic imaging was used to assess single-cell neutrophil metabolism under various activation conditions.
Findings emphasize the importance of understanding neutrophil metabolic activity for therapies in inflammatory diseases.

Datta et al. (2025) studied this question.

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