Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
August 7, 2025Cell Death and DiseaseOpen Access

ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer

View Full Paper
Ask AI
Bookmark
Share

Authors

XXXiaozhou XieYZYulong ZhaoJLJin Liu

Discussion

Loading...

Member takes

Overview

Analysis identifies ZC3H13's role in regulating SNTB1 and facilitating EMT in gastric cancer, highlighting its prognostic impact.

Key Points

  • ZC3H13 is significantly upregulated in gastric cancer, contributing to patient poor prognosis.
  • The study uncovers ZC3H13's role in promoting proliferation, invasion, and migration of GC cells.
  • Mechanistically, ZC3H13 mediates YTHDF1-dependent m6A modification of SNTB1, leading to EMT activation.
  • Findings suggest that targeting ZC3H13 could be a new therapeutic approach for managing gastric cancer.

Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/689dfea6d61984b91e13c71ehttps://doi.org/10.1038/s41419-025-07889-2
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ZC3H13‐mediated m6A stabilization of CCND1 promotes malignant progression and is associated with poor anti‐PD‐1 response in HNSCC2026
  2. 2The role of ZC3H13 in promoting M2 macrophage infiltration via m6A methylation in esophageal squamous cell carcinoma tumor progression2025 · 5 citations
  3. 3METTL3-Regulated lncRNA SNHG7 Drives MNNG-Induced Epithelial–Mesenchymal Transition in Gastric Precancerous Lesions2024 · 10 citations
  4. 4hsa_circ_0101050 regulated by ZC3H13 enhances tumorigenesis in papillary thyroid cancer via m6A modification2024 · 5 citations
  5. 5Identification of ZNF469 as a potential biomarker and therapeutic target for gastric cancer through integrated multi dataset analysis2026