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September 5, 2025Frontiers in ImmunologyOpen Access

The role of ZC3H13 in promoting M2 macrophage infiltration via m6A methylation in esophageal squamous cell carcinoma tumor progression

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Authors

QYQihang YanCXChendi XuLGL. Gong

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Overview

Bioinformatics reveals ZC3H13's role in m6A methylation and M2 macrophages, suggesting key tumor microenvironment interactions.

Key Points

  • ZC3H13 promotes M2 macrophage infiltration, enhancing tumor progression in esophageal squamous cell carcinoma.
  • Silencing ZC3H13 inhibited tumor growth and M2 macrophage presence, indicating its crucial role in the tumor microenvironment.
  • M6A methylation modification stabilizes CXCL8 mRNA, thereby facilitating M2 macrophage polarization in esophageal tumors.
  • The study underscores the CXCL8-CXCR2 axis as significant for M0-M2 macrophage transition in the tumor microenvironment.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/68bb49bc6d6d5674bccff5dfhttps://doi.org/10.3389/fimmu.2025.1612041
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