This study demonstrates bispecific DNA-peptide probes targeting receptor pairs in HUVECs and A549 cells, implying enhanced specificity and internalization.
Key Points
This research identifies bispecific DNA-peptide probes for targeting specific receptor pairs on live cells.
Optimal distances between peptide ligands are crucial for targeting VGFR2/αVβ3 on HUVECs and EGFR/MET on A549 cells.
Systematic spatial screening revealed that distances exceeding 20 nucleotides are needed for effective recognition.
These innovative probes show potential for selective cytotoxicity, combining low molecular weight with efficient internalization into target cells.